Yes, but you will need to use DataAssist as well. Here is the step:
on a new page create a form that have form field for the new email address
the user has to be logged in so you can get the UserID. when the page submit you will create a record set that checks the email address against your users table email address.
If the record set return 0 rows, then you know you can update the user email address using DataAssist Update Server Behavior using the UserID.