Solving problems with Dreamweaver
You didn't mention any error messages or anything about your operating environment, but I would start with step 1:
Also make sure that you are using the latest version of the extensions you are using.
This might help as well:
10 Tips for getting quick help from a support forum
The more we know about your issue the more likely it will be that someone can help you. Otherwise the WA guys will be back on Monday.