Create new theme from scratch?

I would like to create my own theme from scratch.

I have studied the theme layout and have a pretty good grasp of how the different plugins work.

I really want to know if I can use my own theme and do away with the configurable css and the design part of the admin. I want to put everything in my new themes main css form.

Is this possible?
Would I hard code something in theme_open.php to go straight to my theme?

I am afraid that this will blow everything up.

I love the features of powerstore but I am not crazy about the designs. Having to go through the admin to change colors and everything else is a pain.
My normal workflow is to create a comp in fireworks and slice it up into various components. Then move over to Dreamweaver layout my fireworks comp with css and add navigation and contnent.

I would just like to be able to add the powerstore plugins to my design. I have all of the webassist extensions but laying out an admin as advanced as powerstore is a little over my head.
I am sure that what I am asking is over the scope of this forum but if it is possible I would be willing to pay for a premium support ticket.