Yes, that is possible, but it does require a lot of work. We do this in our PowerStore solution pack which you can see a demo of at this url:
Your friends over here at WebAssist! These Dreamweaver extensions will assist you in building unlimited, custom websites.
These out-of-the-box solutions provide you proven, tested applications that can be up and running now. Build a store, a gallery, or a web-based email solution.