1) Calculations are performed on a line item basis.
The calculations use a ternary expression. a ternary expression is a shortened if statement:
question?true part:false part
to addd the 2 calculation together, you simply use the plus operator between them:
((abs([tSize] == '2XL' || [tSize] == '3XL'))?[Price] + 3:[Price] + (abs([sSize] == '2XL' || [sSize] == '3XL'))?[Price] + 5:[Price])
I thing the correct calculation though for your needs would be:
[Price] + (((abs([tSize] == '2XL' || [tSize] == '3XL'))?3:0) + ((abs([sSize] == '2XL' || [sSize] == '3XL'))?5:0))
2) Add the pick up check box to the checkout page. Add a hidden form element on the confirm page of the same name to capture the value posted from the checkout page, and add a set session value behaivor to set a session id the checkbox is checked.
on your shipping rules, set a trigger that will cause the shipping to not apply based on the session value.
There are a bunch of threads in this forum that will explain it in more detail.
3) on the checkout page, remove all the other counties from the shipping country selcct list.
4) that can be done using a calculation, the exact details depend on how the quantity should be limited. Do all items get the same limit, or some items have a different limit.
5 + 6) On the charges tab, you will need to create charges that will add the paypal fees.