I just did a test of this with PowerStore2 and iRite 1.0.3. I edited the product insert page by selecting the first iRite instance on the page and editing it. I updated the skin that was used and changed it to the office skin. When I finished I saved the page and previewed it without issue.
Please post back and describe the steps you are taking in regardsto the edits you are making in the iRite instance. I will use your steps to see if I can get the same to happen. Also, have you tried checking on the skin that is selected? Make sure that you have a skin selected in the interface in case this setting was lost during your edits.