Yes, most likely you would have to adjust quite a few other css styles to get it to look correct. Since the designs were created for a fixed width, adjusting it to be used for a variable width site does take a considerable amount of modification.
Your friends over here at WebAssist! These Dreamweaver extensions will assist you in building unlimited, custom websites.
These out-of-the-box solutions provide you proven, tested applications that can be up and running now. Build a store, a gallery, or a web-based email solution.