Yes, you could do that , you would need to add the offerID column to the cart object and in the add to cart button set it to store the offer ID for the specific product

the calculation:
abs([offerID] == '1' && [Quantity] >= '2')?[Price]:0

would set the discount to be the value of [Price] if the offerID is 1 and the quantity is >= 2

the calculation is ternary expression, basically it is a shorthand if statement in the form of:

(Question)?true:false

so lets take an item with the following settings:
Price: 10
offerID:1
quantity: 1

the calculation
abs([offerID] == '1' && [Quantity] >= '2')?[Price]:0

would return 0 because the Quantity is not equal to or greater than 2. the question returns false and 0 is the false part of the calculation.

now set the product as:
Price: 10
offerID:1
quantity: 2

the calculation:
abs([offerID] == '1' && [Quantity] >= '2')?[Price]:0

the question is now true, so returns 10, that is the value of [Price], which is the true part of the calculation

increase quantity to 3 or above, it still returns 10

to create a calculation to apply a 10% discount, the calculation would be:
abs([offerID] == '2')?([Price] * 0.1):0

on this calculation, the product settings:
Price: 10
offerID:2
quantity: 2

would return 1 (10 * 0.1 = 1)

you could add a quantity check in there if you like:
abs([offerID] == '2' && [Quantity] >= '2')?([Price] * 0.1):0

so it only applies if the quantity is greater than or equal 2

or you could add the quantity into the calculation so that an item with quantity 3 would return 3 instead of 1:
abs([offerID] == '2' && [Quantity] >= '2')?(([Price] * [Quantity]) * 0.1):0

(10 * 3 = 30) * 0.1 = 3