It sounds like what you would do is first use CSS Sculptor to style and create your page. Then using Dreamweaver, you can make a Template. Then, you would create new pages based on that Dreamweaver Template. If you wanted to make global changes, you would simply update the Template using Dreamweaver then it will apply the changes to all the pages derived from that Template.
Another solution is to use our SiteAssist Professional extension. SiteAssist Pro allows you to manage your entire site including adding and removing pages. It is also possible to design something in CSS Sculptor, then add that to SiteAssist Pro as a custom preset.