My opinion as a Web Designer (schooled, not book read), is that designing in Wordpress, Drupal, etc, is unprofessional and cheesy. You constantly have to download security updates to protect your site from being hacked, which I have still seen happen even after security updates. Do yourself a big favour, and design your site and insert a cms such as Power CMS into it, instead.
There is much more control on your side of things with this option.
Now I have a security question for the folks at WebAssist which I will post next! :)