Does this happen with every sculptor preset that you edit?
Were you able to save changes to the layouts previously?
Did you make any changes to the Configuration/Commands/wacs_savedesign.js file or the Configuration/Commands/wacs_savedesign.htm file? The Configuration folder is the one referred to in the common installation issues file:
common_installation_issues.pdf
Can you send me these two files so I can take a look at them?