as long as the exchange server server does not require authentication to send the emails, it should work fine.
Power Messenger cannot be used with SMTP servers that require authentication.
Your friends over here at WebAssist! These Dreamweaver extensions will assist you in building unlimited, custom websites.
These out-of-the-box solutions provide you proven, tested applications that can be up and running now. Build a store, a gallery, or a web-based email solution.