This is a permissions error on the folder containing the access database.
It is not a problem with your server. IUSR_machinename must not have full permissions for the access database or the folder where it resides.
Your friends over here at WebAssist! These Dreamweaver extensions will assist you in building unlimited, custom websites.
These out-of-the-box solutions provide you proven, tested applications that can be up and running now. Build a store, a gallery, or a web-based email solution.