no probllem providing you are happy with html and css.
So create your page ie index2.php then using the insert--- template add you editable regions.
Dreamweaver will then create the template, add it to the assets panel and store it in the directory called templates.
So when you have a page you have created select the assets panel and then highlight the template you want to use then select apply and that template will be applied to that page.
As to disconnecting a page from a template again select modify---templates---detatch from template.
Ok fairly easy but make sure you have loads of backups ;-)