Ok, so I cleared the configuration folder again and re-enabled my extensions one at a time.
I started with DataAssist 2.0.6
Digital File Pro 2.0.2
Universal Email 3.0.6
Validation Toolkit 2.3.4
Pro Maps for Google 1.0.4
Database Search 1.4.1 - Dreamweaver crashes
after clearing the config folder again, re-enabling all bar the Database Search Dreamweaver works.
Database Search 1.4.1 is the latest version, as is DataAssist 2.0.6 so this would suggest that there is some incompatibility between the two?