Only problem i got with CMS100 was when i installed PHP 5.3.1, pulled my hair over why i could not get it to work, checked my other PC and there it worked flawless, after several hrs i did a phpinfo on my working site, saw i used php 5.2.11. lol
So i uninstalled 5.3 and got 5.2 instead. Works like a charm on my Windows 7 now again.
Could not get the PHP 5.3 to work good anyways with ISS 7.5.. :S haha
Other then that its pretty straight forward. :)