Yes. It works with CS4 and above. The only thing that won't work is the visual query builder, which requires CS6 and above, but that isn't a necessary piece.
Your friends over here at WebAssist! These Dreamweaver extensions will assist you in building unlimited, custom websites.
These out-of-the-box solutions provide you proven, tested applications that can be up and running now. Build a store, a gallery, or a web-based email solution.