I've built several responsive sites that incorporate Web Assist code. You do have to know what you're doing -- that said it can be done. I've used both Bootstrap and the native Dreamweaver responsive frameworks.
Your friends over here at WebAssist! These Dreamweaver extensions will assist you in building unlimited, custom websites.
These out-of-the-box solutions provide you proven, tested applications that can be up and running now. Build a store, a gallery, or a web-based email solution.