Yes, you can design Spry Elements that you add to your layout using CSS Sculptor.
When Creating a layout using CSS Sculptor V3, you can add Spry Elements. CSS Sculptor V3 also allows you to apply styling to those elements.
CSS Sculptor is a tool for generating CSS Layouts. The CSS Sculptor landing page says the following in the head:
"CSS design made easy with Eric Meyer and WebAssist's easy to use CSS generator"